I-Curcumin iboniswe ukuba iphucule i-Serum Markers ezivuthayo

Iziphumo zophando olutsha olupapashwe kwiphephancwadi i-Biomed Central BMC lubonise ukuba i-turmeric extract yayisebenza njengeparacetamol ekunciphiseni intlungu kunye nezinye iimpawu ze-knee osteoarthritis (OA).Uphononongo lubonise i-bioavailable compound yayisebenza ngakumbi ekunciphiseni ukuvuvukala.

I-Osteoarthritis sisifo esiphazamisayo samalungu e-articular abonakaliswe ngokuphuka kwe-cartilage, i-joint lining, i-ligaments, kunye nethambo elingaphantsi.Ukubonakaliswa okuqhelekileyo kwe-osteoarthritis kukuqina kunye neentlungu.

Ekhokelwa nguShuba Singhal, i-PhD, olu cwaningo lweklinikhi olungahleliwe, olulawulwayo lwenziwa kwiSebe le-Orthopedics ye-Lok Nayak Jai Prakash Hospital / Maulana Azad Medical College, eNew Delhi.Uphononongo, izigulane ze-193 ezifunyanwe ukuba zine-osteoarthritis yamadolo zazingenamkhethe ukuba zifumane i-turmeric extract (BCM-95) njenge-capsule ye-500 mg kabini imihla ngemihla, okanye i-tablet ye-650 mg ye-paracetamol kathathu imihla ngemihla kwiiveki ezintandathu.

I-Knee arthritis iimpawu zentlungu, ukuqina ngokubambisana, kunye nokunciphisa umsebenzi womzimba wavavanywa kusetyenziswa iWestern Ontario kunye neMcMaster Universities Osteoarthritis Index (WOMAC).Emva kweeveki ezintandathu zonyango, uhlalutyo lwabaphenduli lubonise ukuphucuka okuphawulekayo kumanqaku e-WOMAC kuzo zonke iiparameters ezifaniswa neqela le-paracetamol, kunye ne-18% yeqela le-BCM-95 libika i-50% yokuphucula, kunye ne-3% yezifundo eziphawula ukuphuculwa kwe-70%.

Ezi ziphumo zibonakaliswe kakuhle kwiqela le-BCM-95 lamanqaku okuvuvukala kwe-serum: amanqanaba e-CRP ancitshiswa ngu-37.21%, kwaye amanqanaba e-TNF-α anqunywe ngu-74.81%, ebonisa ukuba i-BCM-95 yenza ngcono kuneparacetamol.

Uphononongo lwalulandela uphando lwe-Arjuna oluqhutywe ngaphezu konyaka odlulileyo olubonise ikhonkco elihle phakathi kwe-flagship curcumin formulation kunye nokunakekelwa kwe-osteoarthritic.

"Injongo yophando lwangoku yayikukwakha kwizifundo zangaphambili ukunika ukucaca okungcono kunye neenkcukacha ngokubandakanya abamakishi abaninzi kunye nendlela engcono yokufumana amanqaku," kusho uBenny Antony, umlawuli odibeneyo we-Arjuna."Impembelelo ye-anti-arthritic ye-BCM-95 kwi-osteoarthritis ibangelwa ukukwazi ukulungelelanisa iimpawu ezichasayo ze-TNF kunye ne-CRP."

I-OA yedolo ngoyena nobangela uphambili wokukhubazeka kunye neentlungu phakathi kwabantu abadala kunye nabantu abadala.Kuqikelelwa ukuba i-10 ukuya kwi-15% yabo bonke abantu abadala abangaphezulu kweminyaka engama-60 baneqondo elithile le-OA, kwaye ukuxhaphaka kuphezulu phakathi kwabasetyhini kunamadoda.

"Olu phononongo luqinisekisa kwakhona impembelelo ye-anti-arthritic ye-BCM-95 kwaye inika ithemba elitsha kwizigidi zokuphucula umgangatho wobomi babo," kusho uNipen Lavingia, umcebisi we-brand innovation ye-Arjuna Natural esekelwe eDallas, TX.

"Sifunda ngakumbi malunga neendlela ezisemva kwe-curcumin's anti-inflammatory effect esikholelwa ukuba yisiphumo sokukwazi ukuthintela iimpawu ze-pro-inflammatory, ezifana ne-prostaglandins, i-leukotrienes, kunye ne-cyclooxygenase-2.Ukongeza, i-curcumin ibonakaliswe ukucinezela ii-cytokines ezininzi ze-pro-inflammatory kunye nabalamli bokukhululwa kwabo, njenge-tumor necrosis factor-α (TNF-α), i-IL-1, i-IL-8, kunye ne-nitric oxide synthase, "utshilo u-Antony.

I-BCM-95's unique fusion ye-curcuminoids kunye ne-turmerone-rich-rich rich-oyile ye-oyile yoyisa imiqobo ye-curcumin ye-bioavailability ngenxa yendalo yayo ephezulu ye-lipophilic.